Publications

Researchers like you all over the world use our solutions to capitalize on opportunities and enhance their projects. Read the latest articles, or delve through the archives, to find out where we’ve been able to help scientists like you.

2014

http://dx.doi.org/10.1111/cbdd.12209

Drugs interacting with off-target proteins would bring about side-effects. The identification of the proteins that a drug can bind is thus valuable for evaluating its side-effects. We established a system based on PDB database for screening for proteins a drug could bind. Firstly, all complexes in the PDB database were ...

2014

http://dx.doi.org/10.1371/journal.pone.0087113

Liposarcoma is the most common soft tissue sarcoma, but little is known about the genomic basis of this disease. Given the low cell content of this tumor type, we utilized flow cytometry to isolate the diploid normal and aneuploid tumor populations from a well-differentiated liposarcoma prior to array comparative genomic ...

2014

http://dx.doi.org/10.1358/dot.2014.50.1.2116673

This article provides a comprehensive overview of the 56 new drugs and biologics introduced for the first time in 2013, the largest number in at least a decade. This includes 20 new orphan drugs and 10 first-in-class agents, as well as the first three products bearing the FDA's new Breakthrough ...

2014

Psychiatric disorders like schizophrenia and neurode generative diseases like Parkinson's disease are associated with poly-factorial pathogenic mechanisms, with several neurotransmitter systems closely involved. In addition to the cerebral dopaminergic (DA) system, the serotoninergic (5-HT) system also plays a crucial role in regulating psycho-emotional, cognitive and motor functions in the central ...

2014

http://dx.doi.org/10.3892/or.2013.2847

Paclitaxel is a mainstay of treatment for many solid tumors, and frequently, clinical outcome is influenced by paclitaxel sensitivity. Despite this, our understanding of the molecular basis of paclitaxel response is incomplete. Recently, it has been shown that microRNAs (miRNAs) influence messenger RNA (mRNA) transcriptional control and can contribute to ...