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PLoS One. 2012; 7(1): e30417. doi: 10.1371/journal.pone.0030417

To fully understand cell type identity and function in the nervous system there is a need to understand neuronal gene expression at the level of isoform diversity. Here we applied Next Generation Sequencing of the transcriptome (RNA-Seq) to purified sensory neurons and cerebellar granular neurons (CGNs) grown on an axonal ...


Blood. 2012 January 26; 119(4): 1018–1028. doi: 10.1182/blood-2011-06-363887

Tumor progression usually proceeds through several sequential stages, any of which could be targets for interrupting the progression process if one understood these steps at the molecular level. We extracted nascent plasma cell tumor (PCT) cells from within inflammatory oil granulomas (OG) isolated from IP pristane-injected BALB/c.iMyc(Emu) mice at 5 ...


Cell Reprogram. 2012 February; 14(1): 1–7. doi: 10.1089/cell.2011.0048

The efficiency of embryonic stem (ES) cell derivation relies on an optimized culture medium and techniques for treating preimplantation stage embryos. Recently, ES cell derivation from the preblastocyst developmental stage was reported by removing the zone pellucida from embryos of the most efficient strain for ES cell derivation (129Sv) during ...


OMICS. 2012 January; 16(1-2): 24–36. doi: 10.1089/omi.2011.0049

We have developed a cellular system constituted of human telomerase immortalized fibroblasts that gradually underwent neoplastic transformation during propagation in culture. We exploited this cellular system to investigate gene and miRNA transcriptional programs in cells at different stages of propagation, representing five different phases along the road to transformation, from ...


J Hepatol. 2012 February; 56(2): 326–333. doi: 10.1016/j.jhep.2011.07.026

Background & Aims: The precise mechanisms by which IFN exerts its antiviral effect against HCV have not yet been elucidated. We sought to identify host genes that mediate the antiviral effect of IFN-alpha by conducting a whole-genome siRNA library screen. Methods: High throughput screening was performed using an HCV genotype ...