Publications

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2013

http://dx.doi.org/10.1074/jbc.M113.463984

Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia. Identifying the kinases involved in the pathological phosphorylation of tau may identify novel targets ...

2013

The use of animals for testing and validating new medical devices and surgical techniques has raised ethical issues for a long time. Following the introduction of the Three Rs principle, significant efforts have been made to achieve a reduction in the numbers of animals used in testing. Nevertheless, the number ...

2013

http://dx.doi.org/10.1136/bmjopen-2013-003199

Objectives: To determine whether heterogeneity in interleukin-6 (IL-6), IL-6 receptor and other components of the IL-6 signalling pathway/network, at the gene, transcript and protein levels, correlate with disease activity in patients with rheumatoid arthritis (RA) and with clinical response to tocilizumab. Design: Biomarker samples and clinical data for five phase ...

2013

Species of the Indo-West Pacific shrimp genus Periclimenaeus Borradaile, 1915, can be preliminarily identified using the morphology of the dactylus of the third ambulatory pereiopods. The dactyli of the 60 currently recognised species are illustrated, and are placed into seven discrete groupings. Data is provided on major morphological reports, hosts, ...

2013

http://dx.doi.org/10.1371/journal.pgen.1003823

Agenesis of the corpus callosum (ACC), cerebellar hypoplasia (CBLH), and polymicrogyria (PMG) are severe congenital brain malformations with largely undiscovered causes. We conducted a large-scale chromosomal copy number variation (CNV) discovery effort in 255 ACC, 220 CBLH, and 147 PMG patients, and 2,349 controls. Compared to controls, significantly more ACC, ...