Publications

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2014

In this publication, the Pathway Analysis Tools within MetaCore were used to identifying anti- miRNA oligonucleotides for chronic kidney disease

In this publication, the Pathway Analysis Tools within MetaCore were used to identifying anti- miRNA oligonucleotides for chronic kidney disease

2014

http://dx.doi.org/10.1111/cbdd.12209

Drugs interacting with off-target proteins would bring about side-effects. The identification of the proteins that a drug can bind is thus valuable for evaluating its side-effects. We established a system based on PDB database for screening for proteins a drug could bind. Firstly, all complexes in the PDB database were ...

2014

http://dx.doi.org/10.1016/j.jbankfin.2013.11.032

This paper analyzes the systemic risk effects of bank mergers to test the "concentration-fragility" hypothesis. We use the marginal expected shortfall as well as the lower tail dependence between a bank's stock returns and a relevant bank sector index to capture the merger-related change in an acquirer's contribution to systemic ...

2014

http://dx.doi.org/10.1358/dot.2014.50.1.2116673

This article provides a comprehensive overview of the 56 new drugs and biologics introduced for the first time in 2013, the largest number in at least a decade. This includes 20 new orphan drugs and 10 first-in-class agents, as well as the first three products bearing the FDA's new Breakthrough ...

2014

http://dx.doi.org/10.3892/or.2013.2847

Paclitaxel is a mainstay of treatment for many solid tumors, and frequently, clinical outcome is influenced by paclitaxel sensitivity. Despite this, our understanding of the molecular basis of paclitaxel response is incomplete. Recently, it has been shown that microRNAs (miRNAs) influence messenger RNA (mRNA) transcriptional control and can contribute to ...