Dichloroethylene, 184.108.40.206, Dichloroethylene epoxide, 220.127.116.11, NRSF, 18.104.22.168, 2-(S-Glutathionyl) acetyl glutathione, 2-Chloroacetyl-glutathione, TFCP2, HNF1-alpha, CYP2F1, 2-(S-Glutathionyl) acetyl chloride, S-(2,2-Dichloro-1- hydroxy)ethyl glutathione, GSTA2, HNF4-alpha, CYP2E1, 22.214.171.124, 126.96.36.199, Dichloroacetaldehyde, SP1, 188.8.131.52, 2-Chloroacetyl chloride, 184.108.40.206
Dichloroethylene, a chemical used in the manufacturing of plastics, can cause pulmonary and hepatocellular injury. Mechanism of Dichloroethylene-induced injury involves cytochrome P-450-catalyzed metabolism of this compound resulting in formation of reactive intermediates, such as Dichloroacetaldehyde, Dichloroethylene epoxide, and 2-Chloroacetyl chloride, that bind covalently to bioactive macromolecules in liver. Cytochrome P450, family 2, subfamily F, polypeptide 1 ( CYP2F1 ) and Cytochrome P450, family 2, subfamily E, polypeptide 1 ( CYP2E1 ) are involved in oxidative metabolism of Dichloroethylene , , , . Detoxification of Dichloroethylene is primarily dependent upon availability of reduced glutathione for conjugation. Secondary metabolites are produced as the result of further conjugation reactions that result in the synthesis of S-(2,2-Dichloro-1-hydroxy)ethyl glutathione, 2-(S-Glutathionyl)acetyl glutathione, and 2-Chloroacetyl glutathione. Conjugation with glutathione catalyzed by Glutathione S-transferase A2 ( GSTA2 ) , , .