PtdIns(3,4,5)P3, PKC-delta, PI3K reg class IA (p85-alpha), Phosphatidylcholine, G-protein alpha-o, mTOR, RHEB2, PLC-beta1, SOS1, c-Raf-1, CaMK II, Noradrenaline extracellular region, eIF4E, VAV-2, Ca('2) cytosol, Ca('2+) endoplasmic reticulum, G-protein alpha-q, MEK1(MAP2K1), PLD2, 126.96.36.199, PRK1, MEK2(MAP2K2), PKC-epsilon, Alpha-1A adrenergic receptor, p70 S6 kinase1, c-Src, RhoA, IP3, H-Ras, p70 S6 kinase2, IP3 receptor, PI3K cat class IA (p110-beta), G-protein beta/gamma, Alpha-1D adrenergic receptor, 188.8.131.52, PtdIns(4,5)P2, G-protein alpha-11, Alpha-1B adrenergic receptor, 184.108.40.206, eEF2K, Phosphatidic acid, DAG, Shc, Pyk2(FAK2), eIF4G1/3, Tuberin, ERK2 (MAPK1), None, eIF4A, eEF2, PLD1, 1,2-diacyl-glycerol 3-phosphate, 4E-BP1, Calmodulin
Translation regulation by Alpha-1 adrenergic receptors
Subtype alpha-1 adrenergic receptors consist of Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor. Noradrenaline -activated alpha-1 adrenergic receptors participate in many physiological processes, e.g., in translation activation , , 
These adrenergic receptors activate different Guanine nucleotide binding proteins (G-proteins). For example, all three receptors interact with G-protein alpha-q and G-protein alpha-11 , , . Alpha-1B adrenergic receptor acts through G-protein beta/gamma of pertussis toxin-sensitive Alpha activating activity polypeptide O ( G-protein alpha-o ) , . G-proteins also activate Phospholipase C beta 1 ( PLC-beta1 ) . PLC-beta1 hydrolyzes Phosphatidylinositol-4,5-bisphosphate ( PtdIns(4,5)P2 ) to produce Inositol 1,4,5-trisphosphate ( IP3 ) and 1,2-diacyl-glycerol ( DAG ).
IP3 interacts with Inositol 1,4,5-triphosphate receptor type 3 ( IP3 receptor ) of the endoplasmic reticulum, and this leads to Ca('2+) release. Elevated Ca('2+) level activates Calmodulin/ Calcium/calmodulin-dependent protein kinase II ( CaMK II )/ PTK2B protein tyrosine kinase 2 beta ( Pyk2(FAK2) )/ v-src sarcoma viral oncogene homolog ( c-Src ) . c-Src can activate Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) ( PI3K reg class IA (p85-alpha) )/ PI3K cat class IA (p110-beta) directly , ,  or via SHC (Src homology 2 domain containing) transforming protein 1 ( Shc )/ Son of sevenless homolog ( SOS )/ v-Ha-ras Harvey rat sarcoma viral oncogene homolog ( H-Ras ) .
Activated PI3K catalyzes transformation of PtdIns(4,5)P2 to Phosphatidylinositol-3,4,5-trisphosphate ( PtdIns(3,4,5)P3 ). Presumably, then PtdIns(3,4,5)P3 then activates Shc/ SOS/ H-Ras. H-Ras then activates v-raf-1 murine leukemia viral oncogene homolog 1 ( c-Raf-1 )/ Mitogen-activated protein kinase kinases 1 and 2 ( MEK1(MAP2K1) and MEK2(MAP2K2) )/ Mitogen activated protein kinase 1 ( ERK2(MAPK1) ) , .
ERK2(MAPK1) activates Tuberous sclerosis 2 ( Tuberin ) / Ras homolog enriched in brain ( RHEB2 )/ FK506 binding protein 12-rapamycin associated protein 1 ( mTOR )/ Ribosomal protein S6 kinase 70kDa polypeptide 1 and 2 ( p70 S6 kinase1 and p70 S6 kinase2 )/ Eukaryotic elongation factor-2 kinase ( eEF2K )/ Eukaryotic translation elongation factor 2 ( eEF2 ).
Also, mTOR activates Eukaryotic translation initiation factor 4E binding protein 1 ( 4E-BP1 ) release from Eukaryotic translation initiation factor 4E ( eIF4E ) that in turn activates group Eukaryotic translation initiation factor 4 gamma ( eIF4G1/3 )/ Eukaryotic translation initiation factor 4A ( eIF4A ) , , . PKC-delta seems participate in activation of mTOR and inhibition of 4E-BP1 . PKC-delta phosphorylates 4E-BP1 synergistically with mTOR .
Moreover, Alpha-1A adrenergic receptor may participate in protein synthesis stimulation via Pyk2(FAK2) )/ c-Src/ Phospholipase D1 and D2 pathway ( PLD1 and PLD2 ) , . PLD1 and PLD2 participate in reaction of Phosphatidic acid production, which then activates mTOR, thus stimulating translation via eEF2 and/or eIF4A , .